Reporting the findings: Absolute vs relative risk
Absolute Differences between the effects of two treatments matter more to most people than Relative Differences.
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Explaining the mission of the AllTrials Campaign (TED talk)
Half the clinical trials of medicines we use haven’t been published. Síle Lane shows how the AllTrials Campaign is addressing this scandal.
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Tipsheet for reporting on drugs, devices and medical technologies
Questions that will be familiar to reporters covering health and medicine.
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Tips for understanding Intention-to-Treat analysis
Ignoring non-compliance with assigned treatments leads to biased estimates of treatment effects. ITT analysis reduces these biases.
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Tips for understanding Absolute vs. Relative Risk
Absolute Differences between the effects of two treatments matter more to most people than Relative Differences.
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Tips for understanding Non-inferiority Trials
A non-inferiority experiment endeavours to show that a new intervention is ‘not unacceptably worse’ than the comparison intervention.
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Tamiflu: securing access to medical research data
A campaign by researchers has shown that Roche spun the research on Tamiflu to meet their commercial ends.
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Introduction to JLL Explanatory Essays
Professionals sometimes harm patients by using inadequately evaluated treatments. Research addressing uncertainties can reduce this harm.
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Recognizing researcher/sponsor biases and fraud
The vested interests of researchers and organizations tend to be reflected in reports of treatment research in which they are involved.
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Video games and health improvement: a literature review of randomized controlled trials
This is a critical appraisal of a non-systematic review of randomized trials of video games for improving health.
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Surrogate markers may not tell the whole story
A webpage explaining the limitations of using surrogate outcome markers in clinical research.
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Mixed Messages about Statistical Significance
A webpage explaining the difference between statistical and practical significance.
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Testing Treatments Audio Book
The Testing Treatments Audiobook enables visitors to the TTi site to select whichever chapters in the book they would like to listen to.
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7 words (and more) you shouldn’t use in medical news
A webpage explaining that dramatic effects of medical treatments are very rare.
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Observational Studies – does the language fit the evidence?
A webpage explaining observational studies and their advantage and disadvantages.
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John Ioannidis, the scourge of sloppy science
A 8 min podcast interview with John Ioannidis explaining how research claims can be misleading.
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Science Weekly Podcast – Ben Goldacre
A 1-hour audio interview with Ben Goldacre discussing misleading claims about research.
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How do you know which healthcare research you can trust?
A detailed guide to study design, with learning objectives, explaining some sources of bias in health studies.
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CASP: making sense of evidence
The Critical Appraisal Skills Programme (CASP) website with resources for teaching critical appraisal.
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Can measurements show if a treatment works?
An article discussing errors to avoid when testing treatments.
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More than average confusion about what mean means mean
Cartoon and blog about how averages can hide important variations in effects.
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Animal and Lab studies
A webpage explaining how results from animal studies may not be transferable to humans.
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Commercialism
A webpage about commercialism and conflicts of interest in health research.
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Be careful with composites
Kevin Lomangino's article discusses the limitations of composite outcomes and surrogate markers.
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AllTrials: All Trials Registered | All Results Reported
AllTrials aims to correct the situation in which studies remain unpublished or are published but with selective reporting of outcomes.
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Fair tests of treatments: a quick guide for journalists
When deadlines are pressing, how can journalists tell whether to believe claims about the effects of a new treatment or breakthrough?
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Evidence Based Medicine Matters: Examples of where EBM has benefitted patients
Booklet containing 15 examples submitted by Royal Colleges where Evidence-Based Medicine has benefited clinical practice.
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What does the Cochrane logo tell us?
This video and animated slide presentation prepared by Steven Woloshin shows how the Cochrane logo was developed, and what it tells us.
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บทที่ 1 ใหม่กว่าแล้วดีกว่าไหม
ประเด็นสำคัญ การตรวจสอบวิธีเป็นเรื่องจำเป็น เพราะวิธีการรักษาใหม่มีโอกาสพอๆ กันที่จะแย่กว่า หรือดีกว่าวิธีการรักษาที่ใช้กันอยู่ การตรวจสอบวิธีการรักษาที่ (ไม่เที่ยงธรรม) อาจทำให้ผู้ป่วยทุกข์ทรมานและเสียชีวิต วิธีการรักษาที่อนุมัติให้ใช้แล้วก็ใช่ว่าปลอดภัยเสมอไป ต้องใช้เวลาระยะหนึ่งกว่าอาการข้างเคียงจากวิธีการรักษาจะปรากฏ จากวิธีการรักษามักถูกเน้นเกินจริง ขณะที่มักถูกกลบเกลื่อน ทำไมต้องมีการตรวจสอบวิธีการรักษาอย่างเที่ยงธรรม หากขาดการประเมินอย่างเที่ยงธรรม…คือไม่ลำเอียง…ก็อาจมีการสั่งใช้วิธีการรักษาที่ไม่ได้ผลหรือกระทั่งเป็นโทษเพราะนึกว่ามีประโยชน์ หรือตรงข้าม การรักษาที่ได้ผลก็อาจถูกละเลยเพราะมองว่าไม่มีประโยชน์ จึงควรตรวจสอบอย่างเที่ยงธรรมกับวิธีการรักษาทุกวิธี โดยไม่ต้องสนใจว่ามันมีที่มาอย่างไร หรือเป็นวิธีมาตรฐานหรือวิธีเสริม/ทางเลือกหรือไม่ ไม่ควรเชื่อทฤษฎีเกี่ยวกับผลของวิธีการรักษาที่ยังไม่ได้ตรวจสอบ […]
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GET-IT provides plain language definitions of health research terms